Chonburi Hospital Journal-วารสารโรงพยาบาลชลบุรี

Aromatherapy: The Science of Scents for Holistic Wellness

Natrada Burusliam — 2025-11-21

“The Science of Scents” It is another approach to holistic health care which reflects the therapeutic nature of using natural plant fragrances in physical and mental recovery. Nowadays, this science is used in both western styles which calls aromatherapy and in oriental style, especially in Thailand, which calls Suwakontha therapy. Both approaches have similar goals, but interestingly they have different origins, ideas, and methods. This science has its roots in many cultures. Egyptians and Greeks used plant oils in therapy and also in religious ceremonies. In the eastern world, oil from sandalwood or citronella has been used to dispel anxiety and cleanse the mind, while the Chinese and Indians use herbal aromas to maintain balance of the body. In the modern era, aromatherapy has been revived by French chemist, Rene-Maurice Gattefossé.which discover the healing properties of essential oil from lavender in the early 20^th century.

Congenital Craniofacial Abnormalities

Pattira Tantipasawasin — 2025-09-01

Congenital craniofacial abnormalities affect growth of the skull and face result in craniofacial deformities, limited brain development, increase intracranial pressure and disturb blood brain circulation and also cerebrospinal fluid in the brain. Most of these disorders are caused by craniosynostosis. The severity of the craniofacial deformities and brain development depend on the age of onset, the number and location of the associated cranial sutures involvement. The incidence rate was found between 1 to 2,100 and 1 to 2,500 of live birth around the world. They are classified into 2 types: non-syndromic craniosynostosis and syndromic craniosynostosis. The most common non-syndromic craniosynostosis are sagittal craniosynostosis (60%), unicoronal craniosynostosis (15-20%), bicoronal craniosynostosis (5-10%), metopic craniosynostosis (15%) and lambdoid craniosynostosis (2%) The most common types of syndromic craniosynostosis are Muenke syndrome, Crouzon syndrome, Saethre-Chotzen syndrome, Pfeiffer syndrome and Apert syndrome. Although craniosynostosis is a rare craniofacial deformity in Thailand. it leads to the disability and impairment of the nervous system, intelligence, and learning ability. Early diagnosis and appropriate treatment are important to reduce disability and improve the quality of life.

The Adjunctive Therapy for Chronic Wound : A Review of Pulsed Electromagnetic Field Therapy

Jiranuch Thammakumpee — 2025-08-31

Chronic wounds present a significant challenge in dermatological and surgical practice. This review explores the therapeutic potential of Pulse Electromagnetic Field (PEMF) therapy as an adjunctive treatment for various chronic wound types encountered in dermatology. We delve into the characteristics of chronic wounds, standard treatment approaches, the mechanisms of action by which PEMF promotes wound healing, its clinical applications, and the evidence supporting its efficacy.

Table of Content

Sittichai Tantipasawasin — 2025-09-01

A 3-year-old Thai boy from Chonburi Province came with a lump on the back of the right ear for 2 weeks.

Woranart Ratanakorn — 2025-08-31

A 3-year-old Thai boy from Chonburi Province came with a lump on the back of the right ear for 2 weeks.

Physical examination found a round mass 1.5 cm in diameter at the posterior auricular area, smooth surface, not tender, not movable

The patient has been mass excision done.

Intraoperative found soft consistency mass, 2 cm in diameter, skull defect beneath the mass

The skull films and the histo-pathological sections were shown in the picture

Question

Please describe what you find from skull films
What is a diagnosis?
Which the special stains might helps in the diagnosis?

Woranart Ratanakorn, MD woranartr@hotmail.com

Masthead

Sittichai Tantipasawasin — 2025-09-01

Editor

Sittichai Tantipasawasin, D.D.S. Chonburi Hospital, Thailand

Segmental Editor

Sittichai Tantipasawasin, D.D.S. Chonburi Hospital, Thailand

Woranart Ratanakorn, MD. Chonburi Hospital, Thailand

Advisory

Numphol Danpipat, MD. Chonburi Hospital

Assistant Professor Paisan Kangvonkit, D.D.S. Mae Fah Luang University

Jirasak Kanchanapongkul, MD. Private Hospital

Somprasong Tongmesee, MD. Chonburi Hospital

Editor Board

Emeritus Professor Pirom Kamolratanakul Chulalongkorn University

Professor Aurasa Waikakul Mahidol University

Associated Professor Somchai Satesirisombat Chulalongkorn University

Associated Professor Kampanart Huanbutta Eastern Asia University

Associated Professor Wichit Tharanon Thailand Center of Excellence for Life Sciences

Associated Professor Saowanee Thongnopakun Burapha University

Associated Professor Tanakan Sangnim Burapha University

Associated Professor Kitti Krungkraipetch Burapha University

Sawitree Visanuyothin Maharat Nakhon Ratchasima Hospital

Suchada Anotayanon Chonburi Hospital

Tusanee Choumthong Chonburi Hospital

Porntipa Suparasri Ratchapat University, Chonburi

Chuenrutai Yeekian Queen Savang Vadhana Memorial Hospital

Dechwit Worasayan Chonburi Hospital

Pornpoj Sriuthaisiriwong Chonburi Hospital

Pinit Noorit Chonburi Hospital

Sarawut Thamthanawit Chonburi Hospital

Sombat Apithamsunthorn Aikchol Hospital

Komwuth Konchalard Queen Savang Vadhana Memorial Hospital

Prapap Yuthavisuthi Phrapokklao Chanthaburi Hospital

Kritawit Kritayamaneerat Phrapokklao Chanthaburi Hospital

Pakdee Sannikorn Rajavithi Hospital

Katesiree Kornsithikul Chonburi Hospital

Wasana Hongkan Chonburi Hospital

Sawarat Chaijindaratana Chonburi Hospital

Hatsaya Tantipong Chonburi Hospital

Katkanit Thammakumpee Burapha University

Jindarat Laohathaimongkol Queen Savang Vadhana Memorial Hospital

Jidapa Phuwakonkunlawut Ederly Health Care Center, Thai Red Cross Society

Pattira Tantipasawasin Burapha University

Napaporn Chalermpornpong Phrapokklao Chanthaburi Hospital

Manager

Nichapat Tanmee Chonburi Hospital

Thanagridta Ruangtongma Chonburi Hospital

Tactical EMS Medicine

Sittichai Tantipasawasin — 2025-08-31

Conflicts and wars certainly leading to casualties. It was found that soldiers often died from blood loss from wounds, bleeding in the abdomen from being shot, air leakage in the pleural cavity (tension pneumothorax) and respiratory problems. Therefore, when a soldier is injured, the medical treatment focuses on stopping bleeding first, then take care of breathing,. Wounds, broken bones and burns respectively.

Tactical EMS Medicine

It is out-of-hospital care in combat situations.which is not safe to the soldiers, the injured people. and even through to the aggressors. It is divided into 3 areas as follows: 1.care under fire, 2.tactical field care, and 3. combat casualty evacuation Treatment in each area is different. The main goal is to treat the injured and prevent all those involved from further injury.

Care under fire: Hot zone

Providing treatment in the area of battle. Working in this area is highly risky and has limited resources. The main goal is to stop the bleeding, transport the victrims to a safe area as soon as possible. Emphasis on the safety of personnel.

Tactical field care: Warm zone

Working in this area is still considered a risky area and resources are limited. Even though the shooting has stopped, it should be aware that a new battle may occur at any time. The main goal is treatment to reduce mortality by secure the airway, provide or support the-Breathing, resuscitate the heart and circulation, prevents spinal and neck injuries and quickly transported to a hospital that provides treatment as soon as possible.

Combat casualty evacuation: Cold zone

The main goal is to transport the stable injuried soldiers to a hospital that provides prompt treatment safely. The transportation must be focused on spinal immobilization, so that the injured person does not become paralyzed later.

Risk Factors of Preterm Delivery in Chonburi Hospital

Natthanan Vilairuangchoovong — 2025-09-01

Objective: To determine the transvaginal cervical length and risk factors in the second trimester of pregnancy among preterm delivery.

Material and Methods: This is a retrospective cohort at Chonburi hospital. Inclusion criteria were singleton pregnant women who received antenatal care since 1 Mar 2017, because routine transvaginal cervical length (TVCL) was implemented in singleton pregnancies that underwent transvaginal ultrasound between 16-24 weeks of gestational age. Data such as age, parity, body mass index (BMI), blood pressure, history of preterm birth, smoking behavior, alcohol drinking, gestational diabetes, pregnancy-induced hypertension, serology laboratory test, pap smear result, TVCL, and gestational age at delivery were collected. Data was expressed as mean and median risk factors were analyzed using logistic regression analyses calculated with a 95% confidence interval and a 5% significance level.

Results: A total of 1,010 singleton pregnant women participated in the study, of which, 132 pregnancies developed into preterm deliveries and 878 term deliveries. History of preterm birth, maternal syphilis infection, and pregnancy-induced hypertension were statistically significant risk factors for preterm delivery (OR 12.1, 95% CI 5.6-26.5, OR 3.1, 95% CI 1.1-8.4, and OR 2.4, 95% CI 1.5-4.1, respectively). TVCL and gestational diabetes increased risk in the preterm group but there were no statistically significant differences between the two groups. An additional study found that a short cervical length significantly increased preterm births in the high-risk group.

Conclusion: History of preterm birth, maternal syphilis infection, and pregnancy-induced hypertension were significant risk factors for preterm delivery.

Study on Rational Use of Filgrastim for Febrile Neutropenia Prophylaxis in Patients Receiving Chemotherapy at One Hospital in Health Region 6

Seksun Wongsuriyasak — 2025-08-31

Background: In the year 2017-2019. A hospital in health region 6 had found the febrile neutropenia (FN) in cancer patients after chemotherapy. There were 102 FN. At present there are international guidelines related to the use of group drugs colony-stimulating factors (CSFs) are NCCN 2020¹, ASCO 2015² and EORTC 2010³. All treatment approaches agree on the use of CSFs to prevent FN.

Objective: To study on rational use of filgrastim for febrile neutropenia prophylaxis in patients receiving chemotherapy at one hospital in health region 6.

Materials and methods: Retrospective descriptive study from medical records of cancer patients in the hematologic malignancies of one hospital in health region 6 who received or did not receive filgrastim after chemotherapy from 1 January 2017 - 31 December 2019 in all adult patients.

Results: Number of patients 155 (85 males, 70 females) amounts of chemotherapy receiving 747 cycles (428 males, 319 females) the use of filgrastim compliance with guideline 527 cycles (70.5%) noncompliance 220 cycles (29.5%). From the 747 cycles there were 576 cycles filgrastim used. It was found that rational dose were 574 cycles (99.7%) irrational dose were 2 cycles (0.3%). ANC monitoring after rational duration (ANC>1500) were 172 cycles (29.9%) irrational duration were 404 cycles (70.1%). ANC had been monitored before and after filgrastim injection (rational) 230 cycles (39.9%). Irrational monitored were 346 cycles (60.1%).

Conclusion: The use of filgrastim noncompliance with NCCN guideline 29.5%. The filgrastim cost is 637,880 baht.

Effectiveness of ‘SMART TEETH’ Program on Oral Health Literacy, Oral Health Care Behaviors, Plaque Index and Oral Health Quality of Life among Elementary School Students in Si Sa Ket Provencal Municipality

Karnchanok Somchai — 2025-09-01

This quasi-experimental research investigated the effectiveness of the SMART TEETH program on oral health literacy, oral health behaviors, plaque index, and the oral health-related quality of life among primary students of schools under the Si Sa Ket Provincial Municipality. The sample group consisted of 72 individuals divided into an experimental group of 36 and a comparison group of 36. The experimental group received the SMART TEETH program over a period of 12 weeks, and included lectures, demonstrations, practical exercises, and peer learning exchanges within the group. Meanwhile, the control group received regular dental health education. Data were collected using interviews and analyzed using frequency, percentage, means, standard deviation, paired sample t-tests for intra-group differences, and ANCOVA for differences between the experimental and control groups. The results showed the analysis revealed that the experimental group scored significantly higher than the comparison group in oral health care behaviors (mean difference = 1.44, 95% CI = 0.12-2.76), while there was no statistically significant difference between the groups in oral health literacy (mean difference = -0.72, 95% CI = -5.25-3.84). Additionally, the experimental group had significantly lower scores than the comparison group in plaque index (mean difference = 0.92, 95% CI = 0.58-1.26) and oral health-related quality of life (mean difference = 7.00, 95% CI = 2.90-11.11). Therefore, the SMART TEETH program helps students acquire learning and self-care skills for oral health that can be applied in their daily lives, leading to behavioral changes in oral health behaviors and a greater recognition of the importance of oral health care. However, they may not have access to oral health information from other sources. Nevertheless, parents and teachers should continue monitoring students' behaviors in the long term, and schools should support diverse oral health learning resources to enhance students' learning and access to oral health services.

Vancomycin Dose Optimization of the Patients with Septic Shock in Chonburi Hospital

Tanisa Lexnoi — 2025-09-01

Vancomycin's pharmacokinetic characteristics changed in septic shock patients, resulting in physiological changes, caused high serum drug concentration that led to toxicity or a subtherapeutic dose of the drug to reach the therapeutic target of infection. Optimizing the dosage of vancomycin improves effectiveness and reduces side effects. The aim of our study was to determine to optimize vancomycin dose in septic shock in Chonburi hospital. Serum vancomycin samples from septic shock patients hospitalized to Chonburi Hospital between January 1, 2019, and July 31, 2023, were gathered prospectively and retrospectively. Eighty-eight vancomycin-treated septic shock patients were included and 174 vancomycin concentrations were obtained. The mean (SD) age was 58 (17) years and median creatinine clearance (IQR) was 44.27 (24.00 – 75.28) ml/min. Pharmacokinetic parameters of vancomycin was simulated from vancomycin concentration of each patient. Mean (SD) volume of distribution was 0.80 (0.17) liter per kilogram and median vancomycin clearance was (IQR) 1.39 (0.96 – 3.68) liter per hour, vancomycin dosing was simulated stratified by creatinine clearance to target vancomycin pharmacokinetic with AUC₂₄/MIC 400 – 600 mg·hr/L. According to pharmaceutical database, vancomycin dosing classified by renal function was dissimilar to simulated dose in these septic shock patients especially in moderate to severe renal function (CrCl < 50 ml/min). Therapeutic drug monitor of vancomycin altogether with this recommended dose for septic shock patients would improve efficacy and safety.

The Effects of the Program to Promote Self-Efficacy in Changing Health Behaviors of Hypertension Patients in Chonburi Province

Ubonrat Vichean — 2025-09-01

This study was aimed to study the effects of self-efficacy promotion program in changing health behavior for hypertensive patients in Chonburi Province. There were 60 patients included in this study: 30 patients in the experimental group and 30 patients in the control group. The experimental group used activities to promote self-efficacy in changing health behavior, while the control group did not participate in the program. Data were analyzed using descriptive statistics and results were compared between groups. The statistics used were Independent samples t – test.

The results showed that the experimental group had a higher self-efficacy perception than before the experiment and more than the control group with statistical significance at p<0.05 level. The expectation of performance increased more than before the experiment and more than the control group with statistical significance at p<0.05 level. Health behavior increased more than before the experiment and more than the control group with statistical significance at p<0.05 level. Therefore, this self-efficacy promotion program shall be applied to promote health in other organizations.

Neuroleptic Malignant Syndrome: NMS

Naruttha Norphun — 2025-08-31

Neuroleptic malignant syndrome (NMS) is a complication that can occur and is a significant concern, especially for individuals receiving antipsychotic medications. The condition is characterized by four prominent symptoms (tetrad): altered consciousness, muscle rigidity, fever, and changes in the autonomic nervous system. Most cases have a history of receiving antipsychotic drugs or other medications that cause a rapid alteration in dopamine levels. Although the incidence of NMS is rare, it can lead to severe complications, including rhabdomyolysis, pneumonia, acute kidney failure, sepsis, and death. Diagnosing NMS can be challenging as it needs to be differentiated from other conditions that present with fever and altered consciousness. Treatment involves discontinuing the causative medication and providing symptomatic supportive care. In severe cases, specific medications may be required. However, diagnosis based on clinical symptoms and early treatment is crucial to reducing complications and mortality rates.

Letter from Editor

Sittichai Tantipasawasin — 2025-08-31

Chonburi Hospital Journal

Sittichai Tantipasawasin — 2025-09-01

Instruction

Sittichai Tantipasawasin — 2025-08-31