The comparison of LDL-C estimation formulas

Abstract

Abstract

           The estimation of LDL-C using friedewald equation lacks of accuracy and precision including the inconsistency with the direct measurement LDL-C. Most researchers around the globe and Thailand proposed so many equations, but their limitation depends on the different studying populations. The aim of this study is to compare the estimation of formal equation (Friedewald formula; FF), Chinese formula (CF) and Thai formula (TF) to the direct method for LDL-C. This retrospective study underwent the analysis of lipid profile from diabetic patients in the year 2011. One thousand forty patients’ LDL-C data were calculated by using 3 equations and compared to the direct method. The result shows positive correlation of 3 equations with the direct measurement (r = 0.8463, 0.8439 and 0.8563 respectively) and the mean LDL-C of each equation was lower than the direct LDL-C mean. The results showed all 3 significantly differences of LDL-C calculations from the direct LDL-C (p<0.01). The higher percentage of low risk patients when classified LDL-C into 3 categories using calculated LDL-C would lead to the misdiagnosis of people with dyslipidemia .Therefore the usefulness of reliable direct LDL-C measurement should be considered.

Key words: Lipid profile, Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C), Friedewald Formula (FF), Chinese Formula (CF), Thai Formula (TF), Direct LDL