The Impact of the COVID-19 Pandemic on Treatment Outcomes of rtPA Administration in Ischemic Stroke Patients
Abstract
Background: The COVID-19 pandemic had a significant effect on the public health system in Thailand. In addition to the large number of COVID-19-infected patients, who required substantial resources. This situation also impacted. the diseases that typically require emergency care in normal situations, such as stroke patients.
Objectives: To study the impact of the COVID-19 pandemic on the treatment outcomes of ischemic stroke patients who received rtPA.
Methods: The retrospective study collected data from ischemic stroke patients treated in the emergency department of Chonburi Hospital from January 1, 2018, to December 31, 2021. We considered the period after March 25, 2020, as the onset of the COVID-19 pandemic in Thailand. The study compared the treatment outcome of rtPA administration before and during the COVID-19 pandemic. Data analysis was conducted using STATA version 14 and, the results were presented in terms of mean difference and risk difference.
Results: 170 patients were divided into two groups, with 85 patients in each group, One before the COVID-19 pandemic and the other during the pandemic. Most of them are male, their average age was 61.3 years and their initial NIHSS was about 12. 65.3% of the patients had neurological improvement after rtPA administration. The Door to needle time (51.3±19.5 vs 53.1± 17.3 minutes, p-value 0.51), improved outcomes (70.6% vs 60.0%, p-value 0.11), and mortality (20.0% vs 25.8% , p-value 0,47) did not show statistically significant differences between the two groups.
Conclusions: The COVID-19 pandemic in Thailand did not impact to the treatment outcomes of ischemic stroke patients who were treated with rtPA administration.
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