An Approach to Developing Dissolution Standards for Turmeric Capsules: Paddle Rotating Method

Abstract

A simple dissolution test and standard was developed for turmeric capsules to replace the less discriminating disintegration test stated in the Supplement to Thai Herbal Pharmacopoeia 2004. A previous investigation showed that the rotating device basket was not effective enough for stirring the liquid at the bottom of the vessel. A coning effect due to dense materials in the formulation was observed thus causing variability in the results. Therefore the further study was performed for establishing the standards with paddle instead in 2008. Consequently, the proposed test used the paddle at 75 rpm and dissolution medium composed of 0.05 M hydrochloric acid and sodium lauryl sulfate at 0.6% w/v. The acceptable Q-value was proposed as 75 per cent in 60 minutes.