Risk Factors for Adverse Drug Reactions During Tuberculosis Treatment at Chiangyuen Hospital, Mahasarakham Province.

Abstract

Abstract

            Tuberculosis is still a major health problem in Thailand. Adverse drug reactions (ADRs) are a significant concern during tuberculosis (TB) treatment, potentially leading to poor outcomes and drug resistance. This can cause treatment problems and drug resistance. This study aimed to identify the incidence of ADRs and their associated risk factors to complications during TB treatment at Chiang Yuen Hospital.

            This research was a retrospective study. The data were collected from 289 pulmonary TB patients from 1 October 2021 to 30 September 2024. The data were analyzed using descriptive statistics, Chi-square test, and multivariate logistic regression with p < 0.05. The results were shown by Adjusted Odds Ratio (AOR) and 95% Confidence Interval (95%CI).

            The study found that most patients were male (64.01%) with mean age 53.60 ± 14.80 years. There were 92 patients (31.83%) who had complications during treatment. The most common complications were hepatitis, skin rash, and joint pain. The significant risk factors were age 60 years and older
(AOR = 2.80; 95%CI = 1.60–4.90; p < 0.001), female sex (AOR = 2.10; 95%CI = 1.25–3.50; p = 0.005), having at least one comorbidity (AOR = 1.95; p = 0.006),
liver disease (AOR = 3.10; p = 0.040), and low BMI < 18.5 kg/m² (AOR = 1.85; p = 0.020).

            In conclusion, advanced age, female sex, low BMI, and pre-existing liver disease were significant predictors of ADRs. These high-risk groups should be followed closely during TB treatment for safety and better outcomes.

Keywords : Pulmonary Tuberculosis, Adverse drug reactions, Risk factors, TB Treatment, Community Hospital.