Brain mass in patients with cancer history in Chonburi hospital

Abstract

A retrospective study of 241 patients with brain mass who were admitted in the neurosurgical ward of Chonburi hospital during  30 Dec 2012-30 April 2018.In addition to brain mass , all of them also have systemic cancer which were previously diagnosed or diagnosed at the same time with intracranial lesions. There were 121 males and 120 females in this study. Most of them were 40-79 year of age.Lung cancer is the most frequent systemic cancer  ,found in 138 patients(57.26%).The other were ca breast, ca colon, unknown primary etc. Finding in CT or MRI brain revealed multiple brain masses in124 patients (51.45%),  single brain mass in 112 patients (46.47%) and leptomeningeal enhancement in 5 patients (2.07%).   During the course of disease  211 patients  died during admission,  30 patients had loss to follow up . Brain mass resection were done in 58 patients .The  pathological diagnosis of cerebral metastases were 57 cases . One  case was  astrocytoma grade 2  with history of ca colon for 3 years. The median survival for brain mass in this study was 6 months. Analysis of survival time show no correlation with many factors such as sex, age, primary cancer site, time lag between diagnosis of systemic cancer and brain masses.The factors that correlate with survival time are brain mass resection and characteristic of brain mass.Brain mass resected group has longer survival time than non operated group.Single brain mass group also has better outcome than multiple mass group