The Result of Preterm Prevention Program by Micronized Progesterone Vaginal Suppository in Chonburi Province

Abstract

Purpose: To examine the effect of the preterm prevention program by micronized progesterone vaginal suppository

Design: Descriptive study

Methods: The participants consisted of 243 pregnant women with high risk for preterm pregnancy. They were Thai nationality which gestational age between 20 – 24 weeks and received antenatal care in hospital in Chonburi Province. The program emphasized on screening for preterm pregnancy and individual advisory for prevent preterm labor and consequence of preterm birth. After the participants sign consent forms, they received micronized progesterone vaginal suppository and recommendation for drug used and side effect. Data record in  http://journal.cbh.moph.go.th/drug. Home visit telephone provided by Chonburi hospital staff. Data collection was gathered by the Expected Date of Confinement (EDC), Birth date and Birth weight. Analysis was performed by descriptive statistic and Correlation

Result: The findings revealed that after the program, data could be collected from 146 participants (60.08%). Most of them had previous preterm birth (93.8%) and had previous low birth weight baby (birth weight between 600 – 1,990 grams, average 1,664.04 grams). The participants had 34 preterm births which gestational age less than 37 weeks (23.3%) and 15 participants had preterm births gestational age less than weeks (10.3%). Birth weight was average 2,843 grams (1,100 – 4,200 grams, median 588 grams). There were 28 babies had birth weight less than 2,500 gram (19.2%). There was correlation between gestational age and birth weight with statistically significant (r = 0.755, p = 0.001).

Conclusion: The results of the study suggest that the guideline for preventing preterm labor including screening for risk for preterm labor and using progesterone would be able to prevent preterm birth when compared with unthreatened.