The Prevalence of Statin - Associated Myopathy among Outpatients at Chonburi Hospital

บทคัดย่อ

The purposes of this descriptive research were to study prevalence of statin - associated myopathy among outpatients at Chonburi hospital, risk of myopathy from using statins with another drugs, and relations between doses of statins and liver function, kidney function, muscular function. The samples were outpatients using statins at Chonburi hospital. Data were collected between January 2018 and December 2018. Data were analysis by using descriptive statistics such as percentage, mean, standard deviation and inferential statistics including chi – square tests, logistic regression.

The results revealed that most patients were using simvastatin (94.45%). The prevalence of statin - associated myopathy was 6.9% with simvastatin 6.6%, atorvastatin 8.6%, rosuvastatin 4.4%. Risk of myopathy by using statins with macrolides were 2.91 times, and with amlodipine 1.056 times. Doses of simvastatin and atorvastatin were affected to increase risk of myopathy 1.419, 1.411 times. Effect of myopathy increased when doses of simvastatin and atorvastatin were increased, but safety for increased doses of rosuvastatin statistically significant. Effects on kidney function with increased doses of simvastatin and effects on liver function with increased doses of rosuvastatin were statistically significant. This study suggested that patients with muscle symptoms should received rosuvastatin with awareness of effect on liver function.