Soy Protein for Weight Loss

Abstract

Soy protein may have a beneficial role in obesity. Several nutritional intervention studies indicate that consumption of soy protein reduces plasma cholesterol and triglyceride. This review concludes the evidence on the possible mechanisms for soy protein showing beneficial effect on obesity. Soy protein appears to act through various mechanisms. It helps increasing the level of mRNA of PPAR- α and its activities, reducing the expression of the hepatic SREBP-1, reducing insulin secretion or increasing hepatic removal to reduce insulin/glucagon ratio. Soy protein intake also increased β oxidation by activated several lipogenic enzymes. Furthermore, soy protein increases in circulating levels of cholecystokinin, which regulates satiety and lipolysis. Another possible mechanism of action of soy protein is via stimulation of adiponectin and increased production of thyroid hormone. These mechanisms due to improve obesity by inhibiting lipogenesis and enhancing lipolysis in liver and adipocytes.