Prevalence and association of hypovitaminosis D in osteoporotic hip fracture

Abstract

Background: Hypovitaminosis D is associated with altered bone turnover and increase risk of falls and fractures in older adults. Ascertain the prevalence of hypovitaminosis D and the risk factors associated with vitamin D deficiency is important for management to reduce the fracture events in the future. Objective: To identify the prevalence of hypovitaminosis D in osteoporotic hip fracture and its association. Methods: The retrospective descriptive observational cross-sectional study in the Refracture Prevention Program of Lerdsin hospital between June 1, 2019 and December 30, 2020 (duration 2 years and 6 months). The data were collected such as sex, age, weight, medical diseases, calcium, albumin, 25 hydroxy vitamin D level (25OHD), axial bone mineral density and then analyzed by using program SPSS (wilcoxon ranksum test, chi-square test, Fisher exact Probability Test). Result: The prevalence of hypovitaminosis D (25OHD <30 ng/mL) was 84.5 in 516 osteoporotic hip fracture. The prevalence of vitamin D insufficiency (25OHD 20-29 ng/mL), vitamin D deficiency (25OHD 10-19 ng/mL) and severe vitamin D deficiency (25OHD < 10 ng/mL) were 33.9, 39.1 and 11.4 respectively. Female sex is associated with hypovitaminosis D 2.97 times and 3.8 times compared with male sex. Hypoalbuminemia is significantly associated with severe vitamin D deficiency (P< 0.05). Conclusion: Thai patient with osteoporotic hip fracture has high prevalence in hypovitaminosis D (84.5%), especially in female sex and hypoalbuminemia.