The Prevalence of Drug Interactions in Elderly Patients at Ambulatory Car in Chonburi Hospital

Abstract

Abstract : Elderly patients often have many diseases. This is a chance to get polypharmacy  Resulting in risks drug drug interactions(DDIs) , cascade interactions and cause side effects. Some events resulted in disability and death.  

Objective : This research aims to study prevalence drug drug interactions category D,X in Elderly patients at ambulatory care in Chonburi Hospital and We used 2019  American Geriatrics Society Beer’s criteria determine the prevalence of Inappropriate prescribing.

Methods : This cross-sectional study was conducted at ambulatory care in Chonburi hospital. Consecutive sampling study in July 2010. Inclusion criteria were elderly patients age >=65 years and received at least 2 oral medications

Results : A total of 471 patients were included , with a mean age (±SD) of 75.3±5.6 years and 47.8% received drug more than 7 types. The prevalence of category D DDIs was 36.9 95%CI 32.6-41.5, category X DDIs 7.9% 95%CI 5.6-10.7. The top two most common DDIs were Opioid Analgesics plus CNS depressants had a prevalence 14%  95%CI 11.0-17.5 and Clopidogrel plus Omeprazole, with a prevalence of 9.1% 95%CI 6.7-12.1  The overall prevalence of inappropriate prescribing determine by 2019  American Geriatrics Society Beer’s criteria was 36.7%  95%CI 32.4-41.3 The top three inappropriate prescribing were lorazepam had a prevalence 19.7%  95%CI 16.2-23.6 ,prazosin with a prevalence of  8.9% 95%CI 6.5-11.9 and PPI with a prevalence of 7% 95%CI 4.9-9.7                                                          

Conclusions : The prevalence of category D DDIs was 36.9 95%CI 32.6-41.5, category X DDIs 7.9% 95%CI 5.6-10.7. The top two most common DDIs were Opioid Analgesics plus CNS depressants had a prevalence 14%  95%CI 11.0-17.5 and Clopidogrel plus Omeprazole, with a prevalence of 9.1% 95%CI 6.7-12.1