Propofol Consumption and Recovery Time with BIS-guided Comparing to Clinically Guided Total Intravenous Anesthesia

Abstract

The objective of this randomized controlled trial study was to evaluate propofol consumption and recovery time in patients undergoing BIS-guided and clinically guided total intravenous anesthesia (TIVA) without muscle relaxant assisted ventilation via laryngeal mask airway. One hundred and two patients, ASA I-II, 18-65 year scheduled for elective surgery under TIVA at Nopparat Rajathanee hospital were randomly allocated into 2 groups. Propofol infusion was adjusted according to clinical signs in the control group. In BIS group, propofol infusion was adjusted in an effort to achieve a target BIS of 40-60 during maintenance period. There was a significant difference in the mean propofol infusion rate in BIS group comparing with the control group (7.35, 1.56 mg/kg/hr vs 8.88, 2.08 mg/kg/hr) (p< 0.05). After discontinuation of anesthesia, recovery time and time to remove laryngeal mask airway was significantly faster in BIS group comparing with the control group (3.58, 2.81 min. and 4.48, 3.06 min. vs 5.18, 3.55 min. and 6.35, 3.79 min.) (p 0.02, 0.01 respectively). In this study, BIS monitoring could not predict patient movement during surgery. In conclusion, this study showed that BIS monitoring significantly improved dose adjustment of propofol and shortened the recovery time. BIS monitoring, however, was not beneficial to prevent movement during surgery. So it might not improve satisfaction in anesthesia management in this group of patients.