Evaluation of the Declining of Glomerular Filtration Rate for Forecasting the Risk of Chronic Kidney Disease, and Development of “Thai CKD Risk Calculation” Application

Abstract

Declining of the estimated glomerular filtration rate (eGFR) is a parameter for predicting the risk of chronic kidney disease (CKD); and thus it was used as a health indicator for the evaluation of chronic kidney disease (CKD) in healthy and diseased population. The aims of this study are to determine the declined eGFR in a healthy population and to generate reference values for eGFR in males and females. It was conducted as a cross-sectional retrospective data analytical study with a data set of 5,263 individuals age >18 years having annual medical health check-up at Pua Crown Prince Hospital, Nan, Thailand between 2012-2015. The eGFR was calculated using chronic kidney disease epidemiology (CKD-EPI) formula and statistical analysis was performed. It was found that the reference eGFR value of the slope in healthy men was 1.20±0.60 ml/min/1.73 m2 / year and 1.42±0.71 ml/min/1.73 m2 /year in women. The reference eGFR value of the slope in NCD men and women with non-communicable diseases (NCDs) was 3.96±1.98 ml/min/1.73 m2 /year. The reference values of eGFR were used to develop an application for the evaluating of declined eGFR and monitoring of eGFR. This approach could be useful to predict and prevent the development of CKD in healthy individuals and those with NCDs.