Effect of anticoagulants on high sensitivity quantitative determination of cardiac troponin I
Keywords:
anticoagulant, troponin I, Acute Myocardial InfractionAbstract
Background: High sensitivity quantitative determination of cardiac troponin I, usually use for Acute Myocardial Infraction diagnosis. There was reported that plasma specimen could use for troponin I determination and take a short time to prepare the specimen. From the above information, resulting in study the effect of lithium heparin and ethylene diamine tetra acetate (EDTA) as an anticoagulant for collecting the data to create the guidelines for specimen collection in Phare hospital.
Objective: The aim of this study was to evaluate the effect of anticoagulant on high sensitivity quantitative determination of cardiac troponin I.
Study design: The descriptive study on High sensitivity quantitative determination of cardiac troponin I was performed by using specimen without the anticoagulant compared with the heparinized and EDTA specimen. The case were 40 blood donors of Phare hospital, during the period from 10th October 2022 to 30th December 2022.
Results: The result found that the troponin I levels after specimen collected for 30, 60 and 90 minutes in the same type of samples showed no different values. The comparison between heparinized blood and EDTA blood at 30 minutes showed no different in average values. Furthermore, the average values of clotted blood and EDTA blood showed a significantly different values in each duration time at p-value 0.007, 0.005 and 0.004004 respectively.
Conclusion: This study illustrated that the specimen from clotted blood and lithium heparinized blood were a suitable specimen for troponin I determination.
Key words: anticoagulant, troponin I, Acute Myocardial Infraction
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