Acute ischemic stroke treated with intravenous thrombolytic drugs in Phrae hospital -การศึกษาโรคหลอดเลือดสมองตีบหรืออุดตันเฉียบพลันที่ได้รับการรักษาด้วยยาละลายลิ่มเลือดทางหลอดเลือดดำในโรงพยาบาลแพร่

Abstract

Background: Acute ischemic stroke is a neurological emergency condition that requires rapid assessment and treatment, otherwise it can cause high mortality rate. Treatment monitoring and evaluating in this patient group is an important for evaluation and prevent the complications.

Objectives: To study the incidence and risk factors of acute ischemic strokein Phrae hospital. Evaluatingof clinical outcome after treated with intravenous thrombolytic drug in acute ischemic stroke and the incidence of the complications after treatment.

Study design: Retrospectively studied on medical records in adult patients with acute ischemic stroke treated with intravenous thrombolytic drug in ICU of medicine in Phrae hospital from January 2017 - December 2017.

Results:  Seventy-three patients, 33 male patients (45.2%), 40 femalepatients (54.8%) with an average age  66.8±10.8 years old, Non-worsening neurological symptoms after treated with intravenous thrombolytic drugs was 63 patients(88.7%), An average onset to needle time 162.5±43.3 minutes. An average door to needle time 72.6±28.5minutes. An average onset to door time 90±41.3 minutes. An average NIHSS 11.2±5.7. There  were 10 patients(13.7%) with intracerebral hemorrhage after thrombolytic drug. Intracerebral hemorrhage was associated with statistical significantly worsening of clinical outcome(Odds ratio = 144.66, 95%CI:13.19-1585.60)

Conclusions: Treated with intravenous thrombolytic drug in acute ischemic stroke was very effective and reduced disabilities. Controlled of the risk factors can prevent the stroke and maybe decrease incident of intracerebral hemorrhage after intravenous thrombolytic drug.

Keywords: acute ischemic stroke, thrombolytic drugs, intra-cerebral hemorrhage