Outcomes of HAART in HIV-infected Children at Chao Phraya Yomraj Hospital

Abstract

         Chao Phraya Yomraj hospital had used HAART for the HIV-infected children since 2003 which decreased the rates of mortality and opportunistic infections. The objectives of this retrospective  study were to explain the demographic data, mode of transmission, formula of antiretroviral drugs, growth status and to compare the HAART outcomes at 6, 12 months. Those were the mean of the standard growth data ( weight for age Z score (WAZ), height for age Z score (HAZ), body mass index Z score (BMI-Z) ) and the immune status data (CD4%,CD4 count). The data enrolled 55 cases which were collected from OPD cards, IPD records and the HIV-infected children clinic charts from March 2003 to December, 2008. The analysis-data methods were percentage, mean, standard deviation, minimum, maximum and repeated measures ANOVA. Results of the study revealed that 55 cases of HIV-infected children, mostly in the 6-10 age group (52.73%), the 0-5 year group coming second (29.09), mean of age was 8.17 year (2-13.33 year), the ratio of male and female was 1 : 1.2, all cases were infected via vertical transmission from mother to child, 78.18 percent of the cases had received the first regimen. The growth status data of WAZ, HAZ, BMI-Z before treatment were -2.23, -1.86, -1.43, respectively. The immune status data of CD4 % and CD4 count before treatment were 6.99 percent and 163.13 cell/ mm3, respectively. The variable data of WAZ, HAZ, BMI-Z, CD4%, CD4 count at 0, 6, 12 months were compared and showing statistically differences ( p < 0.05 ) in WAZ, BMI-Z, CD4%, CD4 count. The results can be useful to early detect drug resistance or poor adherence. In conclusion, HAART in HIV-infected children can improve growth and immune status after 6 months of the therapy.

Key words: weight, height, body mass index, HAART, HIV, AIDS