Characteristics and Related Factors with the Levels of Hemoglobin Concentration in the Colorectal Cancer Screening using Fecal Immunochemical Test
Keywords:
colorectal cancer, fecal immunochemical test, disease screeningAbstract
Colorectal cancer (CRC) is the fourth most common cancer in worldwide. In Thailand, males were founded more than females, and it has been increasing by age. CRC screening can be useful in preventing and reducing the mortality rate. In particular, the method of fecal immunochemical test (FIT) of which the levels of hemoglobin concentration (f-Hb) can also be brought to define as the surrogate endpoint for predicting the probability of CRC. The objective of this study was to determine the related factors with the 3 levels of f-Hb concentration, including 1-99 ngHb/ml, 100-449 ngHb/ml and >=450 ngHb/ ml. The sudy samples were 1,703 people randomly selected into the study arm of the population-based randomized controlled trail for CRC screening in Nam Phong District, Khon Kaen, Thailand during the period of May, 2016 to December, 2017. They received the FIT and their f-Hb concentration was obtained. Data were analyzed by using descriptive statistics and ordinal logistic regression. The results found that the positive FIT rate was 9.6% of the samples. Higher proportion was observed in men (17.0%); and the aged group was 65-74 years (18.3%), smoking (17.1%), eating more red meat (14.0%), lack of exercise (13.7%), BMI more than 23 kg/m2 (14.0%) and having family history of cancer (13.7%). The only factor of statistical significance was aged group 65-74 years (adjOR=1.65, 1.16 – 2.37, p=0.006). Therefore, people who between 65 to 74 years should be advised to have regular CRC screening. The authors recommended that further study be conducted on the association between food consumption and the levels of f-Hb concentration.
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