Factors Associated with Severe Bacterial Septic Arthritis at NongKhai Hospital
Keywords:
septic arthritis, bacterial septic arthritis, severe sepsisAbstract
Septic arthritis is a medical emergency due to its potential to cause disability and significant mortality. Permanent loss of joint function was found in approximately 25.0-50.0% of survivors, and a mortality rate of 3.0-25.0%. The most common cause is bacterial infection. Delayed diagnosis of bacterial septic arthritis and inadequate or delayed treatment can lead to disability and increased mortality rates. This study aimed to determine (1) the factors associated with severe bacterial septic arthritis at NongKhai Hospital, and (2) the incidence, diagnostic approaches, and treatment of patients with bacterial septic arthritis. The present study method was descriptive by collecting retrospective data from 2016-2023. The factors associated with severe bacterial septic arthritis were analyzed by Univariate analysis. Only factors which p<0.20 were further analyzed by multiple logistic regression (p<0.05). Altogether 202 eligible patients were enrolled. It was found that the factors associated with severe bacterial septic arthritis included age >60 years, eGFR <60 mL/min/1.73 m2, albumin <3.0 g/dL, and HCO3 ≤20 mEq/L (p<0.05). Therefore, patients with bacterial septic arthritis should be evaluated for the factors mentioned above and be closely monitored to reduce the risk of disability and death.
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Ruangpin C, Rodchuae M, Katchamart W. Factors related to surgical treatment and outcomes of thai patients with septic arthritis. J Clin Rheumatol 2019 ;25(4):176-80.
He M, Arthur Vithran DT, Pan L, Zeng H, Yang G, Lu B, et al. An update on recent progress of the epidemiology,etiology, diagnosis, and treatment of acute septic arthritis: a review. Front Cell Infect Microbiol 2023;13:1193645.
Kaandorp CJ, Dinant HJ, van de Laar MA, Moens HJ, Prins AP, Dijkmans BA. Incidence and sources of native and prosthetic joint infection: a community based prospective survey. Ann Rheum Dis 1997;56(8):470-5.
Choi HJ, Yoon HK, Oh HC, Hong JH, Choi T, Park SH.Mortality of septic knee arthritis in Korea: risk factors analysis of a large national database. Sci Rep 2022; 12(1):14008.
Lieber SB, Alpert N, Fowler ML, Shmerling RH, Paz Z. Clinical characteristics and outcomes of patients with septic arthritis treated without surgery. Eur J Clin Microbiol Infect Dis 2020;39(5):897-901.
Long B, Koyfman A, Gottlieb M. Evaluation and management of septic arthritis and its mimics in the emergency department. West J Emerg Med 2019;20(2):331-41.
Holzmeister A, Frazzetta J, Yuan FFN, Cherones A,Summers H, Cohen J, et al. Evaluation for septic arthritis of the native adult knee is aided by multivariable assessment. Am J Emerg Med 2021;46:614-8.
Couderc M, Bart G, Coiffier G, Godot S, Seror R, Ziza JM, et al. 2020 French recommendations on the management of septic arthritis in an adult native joint. Joint Bone Spine 2020;87(6):538-47.
Earwood JS, Walker TR, Sue GJC. Septic arthritis: diagnosis and treatment. Am Fam Physician 2021;104(6):589-97.
Wang J, Wang L. Novel therapeutic interventions towards improved management of septic arthritis. BMC Musculoskelet Disord 2021;22(1):530.
Huang YC, Ho CH, Lin YJ, Chen HJ, Liu SY, Wang CL, et al. Site-specific mortality in native joint septic arthritis: a national population study. Rheumatology (Oxford) 2020;59(12):3826-33.
Nee CM, Kelham SA. Septic arthritis. JAAPA 2022;35(12):55-6.
Koopman WJ, Moreland LW, editor. Arthritis and allied conditions: a textbook of rheumatology. 15th ed. Philadelphia: Lippincott Williams & Wilkins; 2005.
Chan BY, Crawford AM, Kobes PH, Allen H, Leake RL, Hanrahan CJ, et al. Septic arthritis: an evidence-based review of diagnosis and image-guided aspiration. AJR Am J Roentgenol 2020;215(3):568-81.
Bell J, Rasmussen L, Kumar A, Heckman MG, Lesser ER, Whalen J, et al. Septic arthritis in immunosuppressed patients: do laboratory values help? J Am Acad Orthop Surg Glob Res Rev 2020;4(3):e20.00007.
Brown CR, Samade R, Turnquist E, Mickley J, Lynch D, Larkin KTM, et al. Assessment for septic arthritis in immunocompetent and immunocompromised patients: a single-institution study. J Am Acad Orthop Surg 2022; 30(1):27-35.
Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 2005;18(2):383-416.
Chaowagul W, White NJ, Dance DA, Wattanagoon Y, Naigowit P, Davis TM, et al. Melioidosis: a major cause of community-acquired septicemia in northeastern Thailand. J Infect Dis 1989;159(5):890-9.
Abram SFG, Alvand A, Judge A, Beard DJ, Price AJ. Mortality and adverse joint outcomes following septic arthritis of the native knee. Lancet Infect Dis
Ferrand J, Samad YE, Brunschweiler B, Grados F, Dehamchia-Rehailia N, Séjourne A, et al. Morbimortality in adult patients with septic arthritis. BMC Infect Dis 2016;16:239.
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