Detection of Incidence HIV -1 Infection Transmission Rate of HIV -1 from Mother to Child by Nested-PCR Technique in Songkhla and Narathiwat Province-การตรวจหาอาการติดเชื้อเอชไอวี-1 จากแม่สู่ลูก โดยเทคนิค PCR ในจังหวัดสงขลาและนราธิวาส

Abstract

        Regional Medical Sciences Center Songkhla used Nested PCR for detection of human immunodeficiency virus type1 (HIV-1) in infants after treating HIV-1 infected mother with zidovudine (AZT) combined with nevirapine (NVP) for prevention of the transmission of HIV-1 from mother to child. In this research 834 infant’s blood samples were sent from 17 hospitals in Songkhla province
(2001-2005) and 12 hospitals in Narathiwat province (2003-2005). The results showed 56 infants or 6.7 percent of them were HIV positive. These suggested that AZT or AZT combined with NVP treatment was significantly effective in the control of vertical transmission of HIV-1 from mother to child (p < 0.05). Difference of the infection transmission rates of the two groups of 20 percent were reported and verified the supremacy of the AZT plus NVP regimen. Key words: HIV -1 vertical Transmission rate, Nested PCR