Alcohol Drinking and Helicobacter pylori Infection in Peptic Ulcer Patients-การดื่มแอลกอฮอล์ กับการติดเชื้อ Helicobacter pylori ในผู้ป่วยโรคแผลกระเพาะอาหารและสำไส้เล็กส่วนต้น
บทคัดย่อ
This retrospective study was to assess the relationship between alcohol consumption and Helicobacter pylori infection in peptic ulcer. It was carried out from January to June 2004 on peptic ulcer patients who attended the gastrointestinal unit, medicine department of Buddhachinaraj hospital
during 2001-2003 and underwent gastroscopy with biopsy for rapid urease test to determine H. pylori infection. To determine risk effect, a matched-pair case control study was attempted. The cases were peptic ulcer patients who had positive rapid urease test for H. pylori infection. The controls were the peptic ulcer patients who had negative rapid urease test, matching was intended to
control confounding effect of sex, age and education. Detailed data on alcohol consumption in low level (<10 gm/day), moderate level (10-20 gm/day) and high level (>20 gm/day) as well as alcohol and coffee consumption and stress were obtained by interview based on a set of questionnaire.
There were 457 peptic ulcer patients; 17 died, 65 migrated and 175 registered with incorrect addresses, then 200 patients were analyzed descriptively. H. pylori were found in 105 patients (53 percent of the total). Ninety-eight patients reported alcohol consumption (49.0 percent of the total). Out of these 200, 73 matched pairs were used for case-control analysis to prove the effect of alcohol
drinking. There was no significant relationship between alcohol consumption and H. pylori infection. The odds ratio was 0.41 (95% CI 0.22-1.20). The analysis on different levels of alcohol consumption showed that the odds ratio for patient who drank high and low-moderate level compared to nondrinker were 1.50, (95% CI 0.56-4.23) and 0.69 (95% CI 0.17-1.81).
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