Association of BMI levels and drug-induced hepatitis in new tuberculosis patient
Keywords:
Drug induced hepatitis, TB, BMIAbstract
Background: The one cause of death in TB patients is anti-TB drug induce hepatitis and being low BMI is the risk factor of anti-TB drug induce hepatitis. Data from Phrae Hospital showed that TB patients with a low BMI had a high proportion of deaths. The previous studies have found an association between low BMI and anti-TB drug induce hepatitis. But the result remains unclear and adjusting confounder is also did not perform.
Objective: To assess the association between BMI levels and anti-TB drug induce hepatitis in newly diagnosed TB patients.
Study design: The retrospective case control with concurrence case sampling design was perform between 1 January 2019–31 December 2021, The case were the newly diagnosed TB patients with anti-TB drug induce hepatitis, and the control were the newly diagnosed TB patients without hepatitis in 1 to 4 ratios. Covariates of gender, age, BMI, history of alcohol drinking, history of liver disease, DMs, HIVs were considered. Multivariable logistic regression was used for analyzing, showing odds ratio with 95% CI.
Results: The odds of being anti-TB drug induced hepatitis is 1.56 times from low BMI patient compared to normal BMI patient after adjusting covariates of age, gender, history of alcohol intake, history of liver disease and DMs.
Conclusion: We cannot conclude that BMI levels associate with anti-TB drug induced hepatitis in new TB patient. However, low BMI patient tend to have drug induced hepatitis more than others. Close monitoring of liver function and correction of malnutrition patient is crucial.
Keywords: Drug induced hepatitis, TB, BMI
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