Effect of COVID 19 infection on mortality rate at 28 days after ICU admission of ARDS patients in Phrae hospital
Keywords:
COVID-19, acute respiratory distress syndrome, mortality rateAbstract
Background: Acute respiratory distress syndrome (ARDS) is a condition that is a major public health problem of intensive care units around the world and Thailand due to the high mortality rate. Phrae Hospital was found that in 2017-2019 and 2020-2023, there was an increase in the number of ARDS patients who died in hospitals from 65.07% to 72.8% which is covid-19 outbreak period. The study found that COVID-19 infection causes lung fibrosis and results in more severe symptoms in ARDS patients, causing the proportion of deaths among COVID-19-infected ARDS patients in hospitals was increased. However some studies found that there was no difference in proportionate mortality between COVID-19-infected ARDS patients and non-COVID-19-infected ARDS patients.
Objective: To compare the mortality rate between COVID-19 infection and Non-COVID-19 infection in ARDS patients with ventilators after admission and in-hospital death within 28 days at Medical ICU Phrae Hospital.
Study design: Model study Observational retrospective cohort study, a group of patients diagnosed with ARDS who were admitted to ICU Phrae Hospital. This group of patients was divided into an index group (n=55) and contrast group (n=150). We studied the effect of COVID-19 infection compared with non-COVID-19 infection on mortality rate in ARDS patients, analyzed by multivariable Poisson regression models analysis at 95% confidence interval (CI).
Result: The results show COVID-19 ARDS compared with non-COVID-19 ARDS on mortality rate was decreased 6% (95%CI 0.65-1.35). Then adjusting all confounders, the mortality rate of COVID-19 ARDS was decreased by 15% (95%CI 0.57-1.25) compare with non-COVID19 ARDS.
Conclusion: According to our study, there was no statistically significant difference in the mortality rates between Covid-19 and non-Covid-19 ARDS group in ICU setting at Phrae Hospital.
Keywords: COVID-19, acute respiratory distress syndrome, mortality rate
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