Comparison of Ultrasound-guided Transversus Abdominis Plane Block vs Opioids Alone in Patients undergoing Laparoscopic Cholecystectomy under General Anesthesia on Post-operative Pain

Authors

  • Pornpawee Kaewprakop Kalasin Hospital

Keywords:

Transversus Abdominis Plane Block, Laparoscopic Cholecystectomy, Postoperative Pain, Opioids, Ultrasound

Abstract

Background: Minimal Invasive Surgery (MIS), particularly Laparoscopic Cholecystectomy, is increasingly common. Effective postoperative pain management is crucial for enhanced recovery. This study compares the efficacy of Ultrasound-guided Transversus Abdominis Plane (TAP) block versus opioid analgesia alone for postoperative pain control in Laparoscopic Cholecystectomy.

Methods: A prospective, randomized, controlled trial was conducted on 62 patients undergoing elective Laparoscopic Cholecystectomy. Patients were randomized to either a TAP block group (TAP) or a control group receiving opioids alone (NON-TAP). The TAP group received bilateral ultrasound-guided TAP blocks with a mixture containing 20 mL of 0.5% bupivacaine, 20 mL of 2% xylocaine with adrenaline (1:200,000), 1 mL of dexamethasone (4 mg), and 19 mL of normal saline, totaling 60 mL. The anesthesiologist will divide into 15 mL injections for each site (subcostal and lateral TAP block). Postoperative pain scores, opioid consumption, and side effects were assessed.

Results: The TAP group demonstrated significantly lower total morphine consumption (9.3 ± 2.7 mg) compared to the NON-TAP group (14.1 ± 3.6 mg; p-value<0.01). Intraoperative and postoperative morphine consumption was also significantly reduced in the TAP group (p-value< 0.01). Pain scores at rest and during movement in the PACU were significantly lower in the TAP group (p-value< 0.01). There was no significant difference in the incidence of postoperative nausea and vomiting.

Conclusion: Ultrasound-guided TAP block effectively reduces postoperative pain and opioid consumption in patients undergoing Laparoscopic Cholecystectomy.

Keywords: Transversus Abdominis Plane Block, Laparoscopic Cholecystectomy, Postoperative Pain, Opioids, Ultrasound

References

Keir A, Rhodes L, Kayal A, Khan OA. Does a transversus abdominis plane (TAP) local anaesthetic block improve pain control in patients undergoing laparoscopic cholecystectomy? A best evidence topic. Int J Surg. 2013 Nov;11(9):792–4.

Wanich P. Comparison of Ultrasound-guided Transversus abdominis plane block and opioid on pain for postoperative analgesia in Laparoscopic surgery in Krabi hospital: A randomized controlled trail. Krabi Med J. 2022 Dec;Vol.5(2):27–37.

Elsharkawy H. Ultrasound-Guided Transversus Abdominis Plane and Quadratus Lumborum Nerve Blocks [Internet]. NYSORA; 2018 [cited 2023 Jun 4]. Available from: https://www.nysora.com/topics/regional-anesthesia-for-specific-surgical-procedures/abdomen/ultrasound-guided-transversus-abdominis-plane-quadratus-lumborum-blocks/

Holman SD, Gierbolini-Norat EM, Lukasik SL, Campbell-Malone R, Ding P, German RZ. Duration of Action of Bupivacaine Hydrochloride Used for Palatal Sensory Nerve Block in Infant Pigs. J Vet Dent. 2014;31(2):92–5.

Gouda N, Zangrilli J, Voskerijian A, Wang ML, Beredjiklian PK, Rivlin M. Safety and Duration of Low-Dose Adjuvant Dexamethasone in Regional Anesthesia for Upper Extremity Surgery: A Prospective, Randomized, Controlled Blinded Study. Hand (N Y). 2022 Nov;17(6):1236–41.

Kim BG, Lee W, Song JH, Yang C, Heo GA, Kim H. Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study. Korean J Anesthesiol. 2021 Aug;74(4):317–24.

Zhang Y, Qiao L, Ding W, Wang K, Chen Y, Wang L. Comparison of the effects of perineural or intravenous dexamethasone on thoracic paravertebral block in Ivor‐Lewis esophagectomy: A double‐blind randomized trial. Clin Transl Sci. 2022 Aug;15(8):1926–36.

Bernard R. Fundamentals of biostatistics. 5th ed. Duxbery: Thomson learning; p. 307.

Bernard R. Fundamentals of biostatistics. 5th ed. Duxbury: Thomson learning; 2000. p. 384–385

Kirksey MA, Haskins SC, Cheng J, Liu SS. Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualitative Review. PLoS One. 2015 Sep 10;10(9):e0137312. Doi: 10.1371/journal.pone.0137312.

Kim DH, Liu J, Beathe JC, Lin Y, Wetmore DS, Kim SJ, et al. Interscalene Brachial Plexus Block with Liposomal Bupivacaine versus Standard Bupivacaine with Perineural Dexamethasone: A Noninferiority Trial. Anesthesiology. 2022 Mar;136(3):434-447. Doi: 10.1097/ALN.0000000000004111.

Huynh TM, Marret E, Bonnet F. Combination of dexamethasone and local an-esthetic solution in peripheral nerve blocks: A meta-analysis of randomized controlled trials. Eur J Anaesthesiol 2015 Nov; 32(11):751-8.

Zhao X, Tong Y, Ren H, Ding XB, Wang X, Zong JX, et al. TransversusAbdominis Plane Block for Postoperative Anal-gesia after Laparoscopic surgery: a Systemetic Review and Meta-analysis. Int J ClinExp Med. 2014;7(9):2966-75.

Waitayawinyu P, Siriwannasandha B, Namwong A. Incidence and risk factors of moderate to severe pain in 24 hours after laparoscopic cholecystectomy. Siriraj Med J. 2020 Jul Aug;64(4):119–122.

Published

2025-07-25

How to Cite

แก้วประกอบ พรปวีณ์. 2025. “Comparison of Ultrasound-Guided Transversus Abdominis Plane Block Vs Opioids Alone in Patients Undergoing Laparoscopic Cholecystectomy under General Anesthesia on Post-Operative Pain”. Region 3 Medical and Public Health Journal - วารสารวิชาการแพทย์และสาธารณสุข เขตสุขภาพที่ 3 22 (3). Nakhonsawan Thailand:201-10. https://thaidj.org/index.php/smj/article/view/16564.

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นิพนธ์ต้นฉบับ (Original Article)