Effectiveness of Clinical Practice Guideline for the Prevention of Postoperative Nausea and Vomiting (PONV) in Pak Chong Nana Hospital
Keywords:
Clinical practice guideline for prevention of postoperative nausea and vomiting, Effectiveness, Treatment of postoperative nausea and vomiting, Adverse drug reactionAbstract
Background and objective: Postoperative nausea and vomiting (PONV) is the most common and distressing complication and associated with a significantly patient dissatisfaction. The aim of this study was to compare the incidence of PONV within the first 24 hours after general anesthesia between pre and post-intervention groups.
Methods: This was a historical controlled trial conducted at department of Anesthesiology, Pak Chong Nana Hospital during 2019 - 2021. Study size estimation is 196 cases (98 cases per group). The controlled and the study group are pre-/post-clinical practice guidelines study. The data were collected from perioperative records. The statistical analyses were used descriptive statistics, Kaplan Meier survival curve, Log-rank test and Cox proportional hazard analysis.
Results: The baseline data for both groups were not different. The incidence of nausea & vomiting in the study group was lower than the controlled group (0.041/100 and 0.16/100 person-min). Survival time in the study group was 250 minutes (95% CI: 205, -) and in the controlled group was 195 minutes (95% CI: 170, 245). This was statistically significant (p-value = 0.002). The study group was less likely to be at risk of PONV than the controlled group (HR = 0.27; 95% CI: 0.03, 2.71).
Conclusion: This study resulted that Ondansetron and Dexamethasone are effective drugs for the prevention of PONV in intermediate to high risk groups within 24 hours periods of general anesthesia
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