The post-surgery recurrence rate of oral cancer and influencing factors at Chaiyaphum Hospital.
Keywords:
oral cancer, recurrence, risk factor, recurrence-free survivalAbstract
Objective : To evaluate treatment outcomes for oral cancer patients at Chaiyaphum Hospital, focusing on recurrence rates, 5-year recurrence-free survival rates, and potential factors influencing disease recurrence.
Design : This is a retrospective cohort study of patients with oral cancer who underwent surgery at Chaiyaphum Hospital between January 2018 and March 2023.
Result : A total 50 patients were included in the study. Most were male (64.0%) with a mean age of 64.8 years. The most common tumor sites were the tongue (48.0%), followed by the lip (40.0%) and the floor of the mouth (12.0%). Most patients (88.0%) underwent surgery within 30 days of diagnosis. Thirty-eight percent of patients had stage II disease. There were 12 recurrences, resulting in a recurrence rate of 18 per 100 person-years (95% CI:10.17- 31.56). The recurrence-free survival (RFS) rates at 1, 2 and 5 years were 73.8%, 69.9% and 58.3%, respectively. In multivariate analysis, a positive resection margin of less than 5 mm and post-operative radiation were found to be independent predictors of recurrence (HRAdjusted = 13.54; 95% CI 2.79-65.63, p < 0.001 and HRAdjusted = 3.78; 95% CI 1.16-12.31, p = 0.02, respectively).
Conclusion : The study findings highlight the importance of achieving a negative surgical margin in oral cancer resection to reduce the risk of recurrence. This implies the need for continuous skill development among surgeons and close patient follow-up for recurrence surveillance, especially in patients who have received radiation therapy. Further research is also needed to identify additional factors influencing recurrence over extended follow-up periods with a larger sample size.
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