Risk Factors for Multi-Drug Resistant Acinetobacter baumannii Nosocomial Infection, Chaiyaphum Hospital
Keywords:
Risk factors, multi-drug resistant Acinetobacter baumannii, Nosocomial infectionAbstract
Objective: To assess factors associated with multi-drug resistant Acinetobacter baumannii (MDR-AB) nosocomial infection.
Material and Method: The case-control study was conducted in patients admitted to Chaiyaphum Hospital between October 1, 2013 to September, 30, 2014. The study population consisted of 60 cases with MDR-AB nosocomial infection and 120 controls without nosocomial infection. The cases were matched with controls by age and ward of admission with a ratio of 1: 2. The research instruments included demographic data, and patient recording form. Data were analyzed using descriptive statistics, t- test, chi-square test and multivariate logistic regression.
Results: The average age of the present study population was 65.9 ± 15.7 years among cases and 59.5 ± 18.2 years among controls. The mean of length of stay in hospital among cases was 36.4 ± 23.6 days and controls 5.2 ± 9.9 days. Multiple logistic regression analysis showed the following associated factors with MDR-AB nosocomial infection: indwelling urinary catheter > 1 week (OR=15.45, 95%CI = 3.47-76.41, p < .001), mechanical ventilation >1 week (OR= 5.33, 95%CI = 2.67-26.01, p = .002), nasogastric intubation > 1 week (OR=10.58, 95%CI = 1.97-64.72, p < .001), prior administration of cephalosporins (OR=3.53, 95%CI =1.54-8.07, p < .001), carbapenems (OR= 5.64, 95%CI = 3.21-18.19, p < .001), quinolones (OR= 4.16, 95%CI = 1.59-32.05, p = .017), and lincosamides (OR= 3.52, 95%CI = 1.46- 20.86, p = .016).
Conclusion: There were many risk factors associated with MDR-AB nosocomial infection, including use of devices and previous antimicrobial therapy. To reduce antimicrobial resistant bacterial nosocomial infection, strict infection control measures must be applied to the patients with these risk factors.
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