Prevalence and Factors Associated with Impaired Fasting Glucose among HIV-infected Patients in Bangbo Hospital, Samut Prakan, Thailand - ความชุกและปัจจัยที่เกี่ยวข้องกับภาวะพร่องของน้ำตาลในเลือดหลังอดอาหารของผู้ป่วยเอชไอวี ที่ติดตามการรักษา ณ โรงพยาบาลบางบ่อ จังหวัดสมุทรปราการ

Abstract

          Diabetes in HIV infection was found to be associated with myocardial infarction and stroke. Impaired fasting glucose (IFG) will progress to diabetes within a few years. Limited data are available on IFG status among HIV-infected patients. We aimed to identify prevalence and define factors associated with IFG among HIV-infected patients in a community hospital of Thailand. Medical record of HIV-infected patients attending the HIV clinic of Bangbo hospital, Samut Prakan, Thailand, between January and December 2014 were reviewed. IFG was defined as fasting plasma glucose level between 100 and 125 mg/dL. Logistic regression analysis was used to define the factors associated with IFG. A total of 287 patients were enrolled. The mean age was 42.8 (SD = 8.9) years and 54.7% of them were males. Of all, 93 patients (32.4%) had family history of diabetes. All patients had received antiretroviral therapy (ART); 67.9% were on nevirapine (NVP)-based, 24.0% were on efavirenz (EFV)-based, and 8.0% were on protease inhibitor (PI)-based regimens. The median duration of taking ART was 5 years, with interquartile range (IQR) of 2-8 years. The median CD4 cell count was 428 (IQR = 310-603) cells/mm”. The prevalence of IFG was 27.9%. In multivariate analysis, only age (OR 1.06; 95% CI, 1.02-1.09, p=0.002) and EFV-based regimen (OR 3.26; 95% CI, 1.716.21, p<0.001) were the factors significantly associated with IFG. IFG is prevalent among HIV-infected patients in Thailand. Screening of this condition should be performed in these patients, particularly in those who are advanced age or taking EFV-based regimen.

Key words: impaired fasting glucose, HIV-infected patients