Prevalence and Factors Associated to Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus of Danchang Hospital, Suphanburi
Keywords:
diabetic nephropathy, prevalence, community hospitalAbstract
Objective : To study the prevalence of diabetic nephropathy, clinical characteristics, antihypertensive drug use, prognosis and factors associated with diabetic nephropathy at danchang community hospital
Method : A single-center, retrospective, cross-sectional registry-based in all of type 2 DM patients, age equal to or greater than 18 years old, who were diagnosed diabetic nephropathy according to current criteria during Jan-Dec 2019, in Danchang Community Hospital Suphanburi. The data were collected and reported in descriptive statistics and analyzedassociated factors by multiple logistic regression model, with statistically significance of p<0.05.
Results : The prevalence of diabetic nephropathy was 48.0%, of which microalbuminuria was 46.8%. 61.7% of diabetic mephropathy patients and 25.0%, stage 3 chronic kidney disease used AECi/ARB. statistically significant factors associated with diabetic nephopathy in patient with microalbuminuria patients were male (adjOR 0.45; 95%CI 0.34-0.59, P < 0.001), diabetic duration longer than 10 years (adjOR 1.49; 95%CI 1.14. -1.95, P=0.003), systolic blood pressure greater than or equal to 130 mm Hg (adjOR 4.00; 95%CI 3.07-5.22, P < 0.001) diabetic retinopathy (adjOR 10.06; 95%CI 7.13-14.18, P < 0.001), and peripheral artery disease (adjOR 2.36; 95%CI 1.52-3.67, P < 0.001).
Conclusion : The prevalence of diabetic nephropathy in Dan Chang Hospital was high. The majority of antihypertensive drug use was renin-angiotensin-aldosterone system drugs as. Early screening tests to prevent and slow the progression of kidney disease in diabetic patients with consideration of elderly female patients, HbA1c levels, duration of diabetes and blood pressure control.
Keyword : diabetic nephropathy, prevalence, community hospital
References
วิชัย เอกพลากร. รายงานการสำรวจสุขภาพประชาชนไทยโดยการตรวจร่างกาย ครั้งที่ 5 พ.ศ.2557. นนทบุรี: อักษรกราฟฟิคแอนด์ดีไซน์; 2559.
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329:977-86.
Ngamukos C, Bunnag P, Kosachunhanun N, Krittiyawong S, Leelawatana R, Prathipanawatr T, et al. Thailand diabetes registry project prevalence, characteristics and treatment of patients with diabetic nephropathy. J Med Assoc Thai 2006; 89(Suppl 1): S37.
KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. Am J Kidney Dis 2007;49(Suppl 2):S12-154.
Ingsathit A, Thakkinstian A, Chaiprasert A, Sangthawan P, Gojaseni P, Kiattisunthorn K, et al. Prevalence and risk factors of chronic kidney disease in the Thai adult population: Thai SEEK study. Nephrol Dial Transplant 2010;25(5): 1567-75.
2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J 2018;39:3021–104.
National Kidney Foundation. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013;3:1–150.
Afkarian M, Zelnick LR, Hall YN, Heagerty PJ, Tuttle K, Weiss NS, et al. Clinical manifestations of kidney disease among US Adults with diabetes, 1988-2014. JAMA 2016;316:602–10.
de Boer IH, DCCT/EDIC Research Group. Kidney disease and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care 2014;37:24–30.
Young BA, Maynard C, Boyko EJ. Racial differences in diabetic nephropathy, cardiovascular disease, and mortality in a national population of veterans. Diabetes Care 2003;26:2392-9.
สมาคมโรคเบาหวานแห่งประเทศไทย ในพระราชูปถัมภ์สมเด็จพระเทพรัตนราชสุดาฯ สยามบรมราชกุมารี. แนวทางเวชปฏิบัติสำหรับโรคเบาหวาน 2560 Clinical practice guideline for diabetes 2017. ปทุมธานี: ร่มเย็น มีเดีย; 2560.
American Diabetes Association. Standards of medical care in diabetes-2020. Diabetes Care 2020;43 (Suppl 1):S1-212.
Wanner C, Inzucchi SE, Lachin JM, Fitchett D, von Eynatten M, Mattheus M, et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med 2016;375:323–34.
Zelniker TA, Braunwald E. Cardiac and renal effects of sodium-glucose co-transporter 2 inhibitors in diabetes: JACC state-of-the-art review. J Am Coll Cardiol 2018;72:1845–55.
Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 2016;375:1834–44.
de Boer IH, Gao X, Cleary PA, Bebu I, Lachin JM, Molitch ME, et al. Albuminuria changes and cardiovascular and renal outcomes in type 1 diabetes: the DCCT/EDIC study. Clin J Am Soc Nephrol 2016;11:1969–77.
Whelton PK, Carey RM, Aronow WS, Casey Jr DE, Collins KJ, Himmelfarb CD, et al. 2017 ACC / AHA / AAPA / ABC / ACPM / AGS / APhA / ASH / ASPC / NMA / PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Hypertension 2018;71:1269–324.
Beddhu S, Greene T, Boucher R, Cushman WC, Wei G, Stoddard G, et al. Intensive systolic blood pressure control and incident chronic kidney disease in people with and without diabetes mellitus: secondary analyses of two randomised controlled trials. Lancet Diabetes Endocrinol 2018;6:555–63.
Malhotra R, Craven T, Ambrosius WT, Killeen AA, Haley WE, Cheung AK, et al. Effects of intensive blood pressure lowering on kidney tubule injury in CKD: a longitudinal subgroup analysis in SPRINT. Am J Kidney Dis 2019;73:21–30.
ONTARGET Investigators, Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008;358:1547–59.
Janjumras K., Pipatsatitpong D. Prevalence of Diabetic Nephropathy in Type 2 Diabetes Mellitus at Somdejprapinklao Hospital. J Med Tech Assoc Thailand 2016;44(1):5508-21.
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