การศึกษาผลของการให้ยา Labetalol ขนาดต่ำเปรียบเทียบกับ Fentanyl ขนาดต่ำในการลดความดันโลหิตและอัตราการเต้นของหัวใจในระหว่างการใส่ท่อช่วยหายใจระหว่างการระงับความรู้สึกทั่วร่างกาย

Srisuda Laithongkom; Saowanee  Chanapan

Authors

Srisuda Laithongkom Sawanpracharak Hospital
Saowanee Chanapan Sawanpracharak Hospital

Keywords:

Labetalol, fentanyl, general anesthesia with endotracheal tube

Abstract

Objective : We aim to compare the efficacy of low-dose Labetalol and low-dose fentanyl administration for attenuation of hemodynamic response to laryngoscopy and intubation in patients who underwent general anesthesia.

Methods : A total of 60 patients, aged 18 to 65 years and ASA physical status I-II, who underwent elective surgery under general anesthesia with endotracheal tube were enrolled in this randomized, double-blind controlled study. The patients were randomly divided into two groups. Group F received intravenous 1.5 mcg/kg fentanyl, and Group L received intravenous 0.15 mg/kg labetalol before induction of anesthesia for 3 and 5 minutes, respectively. Hemodynamic parameters were observed at baseline, post-induction, and after intubation at 1, 3, 5, 8, and 10 minutes.

Results : Mean arterial pressure at 1 minute after intubation was statistically significant lower in the fentanyl group compared to the labetalol group. (Mean arterial pressure group F = 109.1±18.6 mmHg, group L = 119.9±16.6 mmHg, p=0.02). There was no significant difference in heart rate between the two groups.

Conclusion : The dose of 1.5 mcg/kg Fentanyl is more effective for attenuating pressure response to laryngoscopy and intubation than 0.15 mg/kg labetalol.

Keywords : Labetalol, fentanyl, general anesthesia with endotracheal tube

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