Risk Factors for Acute Kidney Injury in Melioidosis Patients at Nongkhai Hospital

Abstract

          Approximately 20% of patients with sepsis were diagnosed with melioidosis at Nongkhai hospital. The incidence of death from melioidosis increases yearly. Some patients developed acute kidney injury (AKI) which had higher risks of death compared to those without AKI. The study concerning AKI is limited both in Thailand and other countries. Therefore, this retrospective cohort study aimed to identify the factors associated with AKI in melioidosis patients admitted in Nongkhai hospital from January 1st, 2017 to December 30th, 2020. The informations of patients with melioidosis diagnosed by isolating of organism form blood or other sites of infection were collected from hospital medical records. The data were analysed for risk factors associated with AKI in melioidosis by chi–square test and multiple logistic regression.
          The results showed that of 155 patients, diagnosed with melio idosis 52 had AKI since admitted in hospital and 21 had AKI after treatment. The total number of melioidosis patients with AKI was 73 (47.1%). The factors associated with AKI were chronic kidney disease (CKD) [p = 0.020, odd ratio 4.303 (95%CI, 1.255–14.750)] and septic shock [p < 0.001, odd ratio 7.841 (95%CI, 2.433–25.269)]. Therefore, the melioidosis patients with these factors should be closely monitored to reduce the risk of AKI.

           Keywords: Melioidosis, Acute kidney injury (AKI), Chronic kidney disease (CKD), Septic shock