Factors Associated with Acute Kidney Injury in Patients Taking Colstin at Nongkhai Hospital
Abstract
Currently, drug–resistant microorganisms are a serious medical problem. The important antibiotic–resistant gram–negative bacteria in Thailand are Acinetobacter baumannii and Pseudomonas aeruginosa. Multi–drug resistance in these bacteria occurred more recently. Therefore, colistin is used again but the main adverse reaction of colistin is acute renal failure. Therefore, the researcher is interested in studying the factors associated with acute renal failure among patients taking colistin. The research design was a retrospective observational study. The samples were 211 patients admitted at Nongkhai hospital from January 1st, 2019 to December 31st, 2020. The information of patients aged 18 years old and over whom received colistin was collected from hospital medical records. The serum creatinine levels were determined at least once before and after colistin administration. Data were analyzed by using descriptive and inferential statistics; frequency, percentage, chi–square test and multiple logistic regression.
The results showed that the incidences of patients with acute renal failure assessed using Acute Kidney Injury Network (AKIN) criteria were 75 cases, accounted for 35.5% of all patients studied. The factors associated with acute renal failure in colistin–treated patients were patients aged over 60 years old (p = 0.005), dyslipidemia (p = 0.019) and maintenance dose of colistin³ > 5 milligram/kilogram/day (p = 0.041).
Keywords: Colistin, Acute renal fail
