Factors Associated with Virological Success in Naïve HIV/AIDS patients Who received ARV at NAPHA clinic in Kumpavapee hospital, Udon Thani. ปัจจัยที่มีความสัมพันธ์ต่อความสำเร็จทางไวรัสในการรักษาโดยการให้ยา ARV ในผู้ป่วยติดเชื้อ HIV/AIDS รายใหม่ ที่มารับบริการที่คลินิกนภา โรงพยาบาลกุมภวาปี จังหวัดอุดรธานี
Abstract
This retrospective analytical research determined the incidence and factors associated with the virological success (Viral load; VL ≤ 50 copies/ml) in naïve HIV/AIDS patients who received antiretroviral therapy (ARV) at NAPHA clinic in Kumpavapee hospital, Udon Thani from 1st October 2013 to 30th September 2017. The patients’ data were collected including sex, age, weight, BMI, level of education, history of alcoholic drinking and smoking, underlying disease, opportunistic infections (OIs) before ARV treatment, OIs prophylactic drugs used, ARV regimens, % adherence, Hb level and CD4 level before treatment and viral load. The data were analyzed using descriptive statistics and the factors associated with the virological success were analyzed using the Chi-square test. A p-value < 0.05 was considered significant.
The study from 169 naïve HIV/AIDS patients with complete data showed that the mean ± SD ages of the patients were 37.10 ± 11.88 years and 52.66% of them were female. Their mean ± SD BMI were 19.78 ± 3.64. The incidence of virological success in HIV/AIDS patients who received ARV therapy was 75.15%. The factors associated with virological success were body weight ≥ 40 kilograms (p-value = 0.012), educated patients (p-value = 0.004), no history of smoking (p-value = 0.036), TDF + 3TC regimen (p-value < 0.019), no bactrim used (p-value = 0.001), no fluconazole used (p-value < 0.001), and CD4 level before therapy ≥ 200 cells/ml (p-value = 0.030). This study suggested that the knowledge can be applied for the surveillance and monitoring of the HIV/AIDS patients who are at risk of virological failure after ARV therapy.
Key words : HIV, ARV, Virological Success
