Prevalence and Pregnancy Outcome of Pregnant Women with COVID-19

Authors

  • Kantika Vongmaneepratip Krathumbaen Hospital, Samutsakhon

Keywords:

COVID-19, pregnancy, pregnancy outcome

Abstract

Objective: This study aimed to identify the prevalence of COVID-19 in pregnant women who came for delivery at Krathumbaen Hospital and to find the association between routes of delivery and pregnancy outcomes regarding maternal and neonatal aspects.

Method: This was a retrospective study of pregnant women who visited for delivery at Krathumbaen Hospital and was diagnosed with COVID-19 from 1 May 2021 to 31 October 2021. Medical records of 70 vaginal deliveries and 70 cesarean deliveries were reviewed. Data were collected and analyzed.

Results: The prevalence of pregnant women who confirmed COVID-19 infection was 13%. The mean maternal age was 29.0 ± 5.5 and 28.5 ± 6.2 years for the vaginal delivery and cesarean section group, respectively. 82.6% of pregnant women with age ≥ 35 years were asymptomatic. Multiparity was dominant in both groups (68.6% and 58.6% for vaginal delivery and cesarean section group). Most pregnant women had had term vaginal deliveries and cesarean sections (92.8% and 90%). Signs and symptoms did not differ between groups, even with favipiravir treatment. According to the X-ray result, 83.5% did not represent pneumonia. Postpartum hemorrhage was not different between groups. In the neonatal aspect, birth weight, weight for gestational age, hypoxemia, and hyperbilirubinemia were not different between groups. The rate of hypothermia and dyspnea were significantly higher in the cesarean section group than in the vaginal delivery group. (p<0.05)

Conclusions: The prevalence of pregnant women with COVID-19 infection was 13%. Due to the higher rate of neonatal hypothermia and dyspnea, both conditions should be aware in COVID-19 women undergoing cesarean section.

Keywords: COVID-19, pregnancy, pregnancy outcome

References

World Health Organization. Coronavirus disease 2019 (COVID-2019): situation report-46 [Internet]. 2020 [Cited 2022 Dec 10]. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_4

Gao YD, Ding M, Dong X, Zhang JJ, Kursat Azkur A, Azkur D, et al. Risk factors for severe and critically ill COVID-19 patients: A review. Allergy. 2021;76(2):428-55.

Jamieson DJ, Rasmussen SA. An update on COVID-19 and pregnancy. Am J Obstet Gynecol. 2022;226(2):177-86.

Wastnedge EAN, Reynolds RM, van Boeckel SR, Stock SJ, Denison FC, Maybin JA, et al. Pregnancy and COVID-19. Physiol Rev. 2021;101(1):303-18.

Ellington S, Strid P, Tong VT, Woodworth K, Galang RR, Zambrano LD, et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(25):769-75.

Jafari M, Pormohammad A, Sheikh Neshin SA, Ghorbani S, Bose D, Alimohammadi S, et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis. Rev Med Virol. 2021;31(5):1-16.

Lassi ZS, Ana A, Das JK, Salam RA, Padhani ZA, Irfan O, et al. A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: Clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity. J Glob Health. 2021;11:05018.

Kotlyar AM, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, Tal O, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021;224(1):35-53 e3.

Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020;370:m3320.

Martinez-Perez O, Vouga M, Cruz Melguizo S, Forcen Acebal L, Panchaud A, Munoz-Chapuli M, et al. Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain. JAMA. 2020;324(3):296-9.

Figueiredo R, Tavares S, Moucho M, Ramalho C. Systematic screening for SARS-CoV-2 in pregnant women admitted for delivery in a Portuguese maternity. J Perinat Med. 2020;48(9):977-80.

Sutton D, Fuchs K, D'Alton M, Goffman D. Universal Screening for SARS-CoV-2 in Women Admitted for Delivery. N Engl J Med. 2020;382(22):2163-4.

San-Juan R, Barbero P, Fernandez-Ruiz M, Lopez-Medrano F, Lizasoain M, Hernandez-Jimenez P, et al. Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain. EClinicalMedicine. 2020;23:100407.

Wang MJ, Schapero M, Iverson R, Yarrington CD. Obstetric Hemorrhage Risk Associated with Novel COVID-19 Diagnosis from a Single-Institution Cohort in the United States. Am J Perinatol. 2020;37(14):1411-6.

Figueiro-Filho EA, Yudin M, Farine D. COVID-19 during pregnancy: an overview of maternal characteristics, clinical symptoms, maternal and neonatal outcomes of 10,996 cases described in 15 countries. J Perinat Med. 2020;48(9):900-11.

Huntley BJF, Huntley ES, Di Mascio D, Chen T, Berghella V, Chauhan SP. Rates of Maternal and Perinatal Mortality and Vertical Transmission in Pregnancies Complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) Infection: A Systematic Review. Obstet Gynecol. 2020;136(2):303-12.

Mirbeyk M, Saghazadeh A, Rezaei N. A systematic review of pregnant women with COVID-19 and their neonates. Arch Gynecol Obstet. 2021;304(1):5-38.

Yang Z, Wang M, Zhu Z, Liu Y. Coronavirus disease 2019 (COVID-19) and pregnancy: a systematic review. J Matern Fetal Neonatal Med. 2022;35(8):1619-22.

Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective cesarean delivery. Obstet Gynecol. 2009;113(6):1231-8.

Lunze K, Bloom DE, Jamison DT, Hamer DH. The global burden of neonatal hypothermia: systematic review of a major challenge for newborn survival. BMC Med. 2013;11:24.

Sarici SU, Serdar MA, Korkmaz A, Erdem G, Oran O, Tekinalp G, et al. Incidence, course, and prediction of hyperbilirubinemia in near-term and term newborns. Pediatrics. 2004;113(4):775-80.

Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. Am Fam Physician. 2002;65(4):599-606.

Fenizia C, Biasin M, Cetin I, Vergani P, Mileto D, Spinillo A, et al. Analysis of SARS-CoV-2 vertical transmission during pregnancy. Nat Commun. 2020;11(1):5128.

Thavarajah H, Flatley C, Kumar S. The relationship between the five minute Apgar score, mode of birth and neonatal outcomes. J Matern Fetal Neonatal Med. 2018;31(10):1335-41.

Published

2023-04-05

How to Cite

วงศ์มณีประทีป กัณฐิกา. 2023. “Prevalence and Pregnancy Outcome of Pregnant Women With COVID-19”. Region 3 Medical and Public Health Journal - วารสารวิชาการแพทย์และสาธารณสุข เขตสุขภาพที่ 3 20 (2). Nakhonsawan Thailand:58-66. https://thaidj.org/index.php/smj/article/view/13161.

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นิพนธ์ต้นฉบับ (Original Article)