Morality Rate of Patients with Chronic Obstructive Pulmonary Disease in Chonburi Hospital

Authors

  • Sopita Ngamwongwan Pranangklao Hospital

Keywords:

chronic obstructive pulmonary disease, COPD, mortality rate, cause of death, risk factor

Abstract

Objective: This study aimed to assess the mortality rate of patients with chronic obstructive pulmonary disease (COPD) in Chonburi hospital.

Methods: Retrospective descriptive cross-sectional study was conducted using medical records of patients with COPD in Chonburi hospital during April 2023 to March 2024.

Results: There were 293 patients with COPD, the deaths were recorded in 21 patients. The mortality rate was 7.2%. Of 21 patients, there were 42.8%, 23.8%, 23.8%, 4.8% and 4.8% of patients died from exacerbation of COPD (ECOPD), pneumonia, sepsis, acute heart failure and prostate cancer retrospectively. Three significant risk factors associated with mortality were chronic kidney disease, low lung function and invasive mechanical ventilation. Patients with chronic kidney disease were 3.56 times more likely to die than those without chronic kidney disease (p-value 0.02). Patients with FEV1 ≥ 50% predicted were 3.12 times and patients with invasive mechanical ventilation were 3.22 times more likely to die compared to those with FEV1 > 50% predicted (p-value0.02) and those without invasive mechanical ventilation (p-value 0.04).

Conclusions: The overall mortality rate was 7.2% in COPD patients in Chonburi hospital. The main cause of death was ECOPD. Chronic kidney disease, severe airway obstruction and invasive mechanical ventilation were risk factors associated with increased mortality in these patients.

Keywords: chronic obstructive pulmonary disease, COPD, mortality rate, cause of death, risk factor

References

World Health Organization (WHO). The top 10 causes of death 2021 [Internet]. Geneva: World Health Organization; 2024 Aug 7 [cited 7 August 2024]. Available from: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death.

Blanco I, Diego I, Bueno P, Casas-Maldonado F, Miravitlles M. Geographic distribution of COPD prevalence in the world displayed by Geographic Information System maps. Eur Respir J. 2019;54(1):1900610. Doi:10.1183/13993003.00610-2019.

Quaderi SA, Hurst JR. The unmet global burden of COPD. Glob Health Epidemiol Genom. 2018;3:e4. Doi:10.1017/gheg.2018.1.

Sin DD, Anthonisen NR, Soriano JB, Agusti AG. Mortality in COPD: Role of comorbidities. Eur Respir J. 2006;28(6):1245-57. Doi:10.1183/09031936.00133805.

Müllerova H, Maselli DJ, Locantore N, Vestbo J, Hurst JR, Wedzicha JA, et al. Hospitalized exacerbations of COPD: risk factors and outcomes in the ECLIPSE cohort. Chest. 2015;147(4):999-1007. Doi:10.1378/chest.14-0655.

Rothnie KJ, Müllerová H, Smeeth L, Quint JK. Natural History of Chronic Obstructive Pulmonary Disease Exacerbations in a General Practice-based Population with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018;198(4):464-71. Doi:10.1164/rccm.201710-2029OC.

Mannino DM, Buist AS, Petty TL, Enright PL, Redd SC. Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study. Thorax. 2003;58(5):388–93. Doi:10.1136/thorax.58.5.388.

Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med. 2005;142:233–39. Doi:10.7326/0003-4819-142-4-200502150-00005.

Whittaker H, Rothnie KJ, Quint JK. Cause-specific mortality in COPD subpopulations: a cohort study of 339,647 people in England. Thorax. 2024;79:202–8. Doi:10.1136/thorax-2022-219320.

Park SC, Kim DW, Park EC, Shin CS, Rhee CK, Kang YA, Kim YS. Mortality of patients with chronic obstructive pulmonary disease: a nationwide populationbased cohort study. Korean J Intern Med. 2019;34(6):1272-8. Doi:10.3904/kjim.2017.428.

Pauwels RA, Lofdahl CG, Laitinen LA, Schouten JP, Postma DS, Pride NB, et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N Engl J Med. 1999:340(25):1948–53. Doi:10.1056/NEJM199906243402503.

Calverley PMA, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. 2007;356(8):775-89. Doi:10.1056/NEJMoa063070.

Celli B, Decramer M, Kesten S, Liu D, Mehra S, Tashkin DP. Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;180(10):948–55. Doi:10.1164/rccm.200906-0876OC.

Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, Mendez RA, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350(10):1005–12. Doi:10.1056/NEJMoa021322.

Owusuaa C, Dijkland SA, Nieboer D, van der Rijt CCD, van der Heide. A Predictors of mortality in chronic obstructive pulmonary disease: a systematic review and meta-analysis. BMC Pulm Med. 2022;22(1):125. Doi:10.1186/s12890-022-01911-5.

Hsu CC, Tung PH, Lin TY, Huang SW, Li TC, Wu BC, et al. Effect of chronic kidney disease on survival in patients with chronic obstructive pulmonary disease. Respir Med. 2025;244:108181. Doi:10.1016/j.rmed.2025.108181.

Navaneethan SD, Schold JD, Huang H, Nakhoul G, Jolly SE, Arrigain S, et al. Mortality Outcomes of Patients with Chronic Kidney Disease and Chronic Obstructive Pulmonary Disease. Am J Nephrol. 2016;43(1):39-46. Doi:10.1159/000442947.

Breen D, Churches T, Hawker F and Paul T. Acute respiratory failure secondary to chronic obstructive pulmonary disease treated in the intensive care unit: A long term follow up study. Thorax. 2002;57:29-33. Doi:10.1136/thorax.57.1.29.

Cuchet P, Iachkine J, Bellal M, Gillard H, Hamelin A, Macrez R, et al. Characteristics and risk factors of intubation in COPD patients with severe acute exacerbation: An exploratory single-center retrospective study. Respir Med. 2025;242:108095. Doi:10.1016/j.rmed.2025.108095.

Gadre SK, Duggal A, Mireles-Cabodevila E, Krishnan S, Wang XF, Zell K, et al. Acute respiratory failure requiring mechanical ventilation in severe chronic obstructive pulmonary disease (COPD). Medicine (Baltimore). 2018;97(17):e487. Doi:10.1097/MD.0000000000010487.

Published

2025-09-18

How to Cite

งามวงษ์วาน โสภิตา. 2025. “Morality Rate of Patients With Chronic Obstructive Pulmonary Disease in Chonburi Hospital”. Region 3 Medical and Public Health Journal - วารสารวิชาการแพทย์และสาธารณสุข เขตสุขภาพที่ 3 22 (3). Nakhonsawan Thailand:263-71. https://thaidj.org/index.php/smj/article/view/16717.

Issue

Section

นิพนธ์ต้นฉบับ (Original Article)